Piezoresistive pressure sensors based on sponge are widely concerned because of their wide strain range, convenient signal acquisition, and good compressibility, yet it is still a challenge to acquire sponge‐based pressure sensors with low cost and excellent sensing performance. Herein, low‐priced FeCl3.6H2O and pyrrole (Py) are dispersed in deionized water to form FeCl3.6H2O/Py solution. Commercial latex sponge is impregnated into this solution to prepare conductive polypyrrole/latex (PPy/latex) sponge through low‐temperature interfacial polymerization. The surface of latex sponge is covered by the micro‐wrinkled PPy, which endows the PPy/latex sponge with a certain electrical conductivity. The specific porous structure and high elasticity of the latex sponge are the basic conditions for PPy/latex sponge excellent piezoresistive behaviors. PPy/latex sponge based piezoresistive pressure sensor shows high sensitivity (0.084 kPa−1 at below 3.12 kPa), wider sensing range (0–85.0%) and long durability over 3800 s (1800 cycles). At the same time, the ability of the PPy/latex sponge based piezoresistive pressure sensor to monitor human movement has been successfully evaluated in some application scenarios, such as bending fingers, grabbing objects, tiptoe rising, and crouching.