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The enzymatic release of a model drug from a polymer carrier inside a tumor using multispectral optical imaging in vivo in nude mice bearing colorectal carcinomas HT‐29 and DLD‐1 is demonstrated. Much higher release rate in vivo from a linear (30 kDa) (N‐2‐hydroxypropyl)methacrylamide‐based polymer compared with a high molecular weight branched (170 kDa) polymer conjugate is observed, probably due...
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