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Summary
Background
Activated protein C (APC) cell signaling is largely reliant upon its ability to mediate protease‐activated receptor (PAR) 1 proteolysis when bound to the endothelial cell (EC) protein C (PC) receptor (EPCR). Furthermore, EPCR‐bound PC modulates PAR1 signaling by thrombin to induce APC‐like EC cytoprotection.
Objective
The molecular determinants of EPCR‐dependent cytoprotective...
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