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Background
Proteolytic cleavage of von Willebrand factor (VWF) by ADAMTS13 is crucial for normal hemostasis. Our previous studies demonstrate that binding of coagulation factor VIII (or FVIII) to VWF enhances the proteolytic cleavage of VWF by ADAMTS13 under shear.
Objectives
Present study aims to determine the mechanism underlying FVIII‐mediated enhancing effect on VWF proteolysis by ADAMTS13...
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