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Summary
Background
We have previously demonstrated that von Willebrand factor (VWF) is essential in platelet‐specific FVIII (2bF8) gene therapy of hemophilia A (HA) with inhibitory antibodies (inhibitors). At the site of injury, platelet adherence is initiated by VWF binding to the platelet GPIb complex.
Objective
To investigate the impact of GPIbα on platelet gene therapy of HA with inhibitors...
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