DOI: 10.1002/jssc.201900340
The cover picture shows the stereoselective liquid‐liquid partition chromatography separation of the antidepressant drug (1S, 4S)‐Sertraline from its medicinal reaction mixtures containing four stereoisomers. Each of the four isomers was selectively distributed in the selected biphasic solvent system added with hydroxypropyl‐β‐cyclodextrin in the aqueous phase. Analysis showed that trans‐isomers was found to be more favorably recognized by cyclodextrin than cis‐isomers, while (1S, 4S)‐isomer was more favorably combined with cyclodextrin than (1R, 4R)‐isomer. A fabricated in‐house analytical countercurrent chromatography was used to optimize the separation conditions. Results showed that complete separation could be achieved for trans‐ and cis‐isomers by conventional elution mode, while recycling elution was necessary for separation of (1S, 4S)‐ and (1R, 4R)‐isomer.