Journal of Orthopaedic Research®

Items from 1 to 20 out of 289 results

article

Growth potential of different zones of the growth plate—an experimental study in rabbits

Stefan Hajdu, Elisabeth Schwendenwein, Gerhard Kaltenecker, Ilonka László, more

Journal of Orthopaedic Research® > 30 > 1 > 162 - 168

Despite clinical efforts to treat growth disturbances only little is known about the growth potential of the different zones of the growth plate. The aim of this study was to investigate the growth potential of different zones of the growth plate. A total of 20 New Zealand White rabbits were used for this experiment. The right and left ulna of each animal were used resulting in a total of 40 ulnae...

article

Association between measures of trochlear morphology and structural features of patellofemoral joint osteoarthritis on MRI: The MOST study

Joshua J. Stefanik, Frank W. Roemer, Ann C. Zumwalt, Yanyan Zhu, more

Journal of Orthopaedic Research® > 30 > 1 > 1 - 8

The sulcus angle has been widely used in the literature as a measure of trochlear morphology. Recently, lateral trochlear inclination and trochlear angle have been reported as alternatives. The purpose of this study was to determine the association between measures of trochlear morphology and patellofemoral joint (PFJ) cartilage damage and bone marrow lesions (BMLs). Nine hundred seven knees were...

article

Vascular endothelial growth factor polymorphisms in patients with steroid‐induced femoral head osteonecrosis

Yun Jong Lee, Jong Seok Lee, Eun Ha Kang, Young‐Kyun Lee, more

Journal of Orthopaedic Research® > 30 > 1 > 21 - 27

To investigate an association between steroid‐induced femoral head osteonecrosis (FHON) and functional vascular endothelial growth factor (VEGF) gene (−2578A/C, −1154A/G, −634C/G, and +405C/G) polymorphisms polymerase chain reaction‐restriction fragment length polymorphism genotyping was performed in 160 patients (86 idiopathic FHON and 74 steroid‐induced FHON) and 160 gender‐ and age‐matched controls...

article

Alterations of overused supraspinatus tendon: A possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology

Mohamed Attia, Alexander Scott, Arlette Duchesnay, Gilles Carpentier, more

Journal of Orthopaedic Research® > 30 > 1 > 61 - 71

Supraspinatus tendon overuse injuries lead to significant pain and disability in athletes and workers. Despite the prevalence and high social cost of these injuries, the early pathological events are not well known. We analyzed the potential relation between glycosaminoglycan (GAG) composition and phenotypic cellular alteration using a rat model of rotator cuff overuse. Total sulfated GAGs increased...

article

Effects of aging and degeneration on the human intervertebral disc during the diurnal cycle: A finite element study

Christopher J. Massey, Corrinus C. van Donkelaar, Edward Vresilovic, Antonios Zavaliangos, more

Journal of Orthopaedic Research® > 30 > 1 > 122 - 128

A significant biochemical change that takes place in intervertebral disc degeneration is the loss of proteoglycans in the nucleus pulposus. Proteoglycans attract fluid, which works to reduce mechanical stresses in the solid matrix of the nucleus and provide a hydrostatic pressure to the annulus fibrosus, whose fibrous nature accommodates this stress. Our goals are to develop an osmo‐poroelastic finite...

article

Effect of anterior cruciate healing on the uninjured ligament insertion site

Brian M. Haus, Ashley N. Mastrangelo, Martha M. Murray

Journal of Orthopaedic Research® > 30 > 1 > 86 - 94

The effect of anterior cruciate healing on the uninjured ligament insertion site after enhanced suture repair with collagen‐platelet composites (CPC) has not yet been defined. In this study, we hypothesized that fibroblasts and osteoclasts would participate in generating histologic changes in insertion site morphology after transection and bioenhanced repair of the ACL, and that these changes would...

article

Three‐dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model

Ming‐Hui Sun, Kwok‐Sui Leung, Yong‐Ping Zheng, Yan‐Ping Huang, more

Journal of Orthopaedic Research® > 30 > 1 > 137 - 143

We aimed to establish a novel approach with 3D high frequency power Doppler ultrasonography (3D‐HF‐PDU) to assess microvasculature at the fracture site in rat femurs by comparing with microCT‐based microangiography. Twenty‐four 9‐month‐old ovariectomized (OVX) osteoporotic rats and age‐matched sham‐ovariectomized (Sham) rats were used for establishing closed fracture models on right femora. At 2,...

article

Migration responses of outer and inner meniscus cells to applied direct current electric fields

Najmuddin J. Gunja, Divya Dujari, Andrew Chen, Alba Luengo, more

Journal of Orthopaedic Research® > 30 > 1 > 103 - 111

Injuries to the inner regions of the knee meniscus do not heal and can result in degenerative changes to the articular surface, ultimately leading to osteoarthritis. A possible stimulus to enhance meniscus healing is to use electric fields that induce galvanotaxis. In this study, a novel characterization of the effects of direct current electric fields on migration characteristics of meniscus cells...

article

The (−1486T/C) promoter polymorphism of the TLR‐9 gene is associated with end‐stage knee osteoarthritis in a Chinese population

Sui‐Lung Su, Hsin‐Yi Yang, Chian‐Her Lee, Guo‐Shu Huang, more

Journal of Orthopaedic Research® > 30 > 1 > 9 - 14

Based on the recent observation that Toll‐like receptors (TLRs) may be involved in the pathogenesis of osteoarthritis (OA) we explored the possibility that human TLR gene polymorphisms are associated with OA. Two separate populations were studied in a two‐stage case–control study with a total of 503 OA patients and 428 healthy controls. The TLR‐2, TLR‐4, and TLR‐9 genotypes were assessed by real‐time...

article

The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full‐length injury in the murine patellar tendon

Nathaniel A. Dyment, Namdar Kazemi, Lindsey E. Aschbacher‐Smith, Nicolas J. Barthelery, more

Journal of Orthopaedic Research® > 30 > 1 > 28 - 36

Tendon injuries are major orthopedic problems that worsen as the population ages. Type‐I (Col1) and type‐II (Col2) collagens play important roles in tendon midsubstance and tendon‐to‐bone insertion healing, respectively. Using double transgenic mice, this study aims to spatiotemporally monitor Col1 and Col2 gene expression, histology, and biomechanics up to 8 weeks following a full‐length patellar...

article

Normal shoulder muscular activation and co‐ordination during a shoulder elevation task based on activities of daily living: An electromyographic study

David H. Hawkes, Omid Alizadehkhaiyat, Anthony C. Fisher, Graham J. Kemp, more

Journal of Orthopaedic Research® > 30 > 1 > 53 - 60

Studies of normal shoulder function have often failed to consider the inter‐relationship between different muscle groups in activities relevant to daily life. Upper limb functional status was assessed in 12 healthy male volunteers using the Functional Impairment Test‐Hand, Neck, Shoulder and Arm test (FIT‐HaNSA). Electromyography was then used to study the activity and coordination of 13 muscles (10...

article

Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells

Cornelia Neidlinger‐Wilke, Antje Mietsch, Christina Rinkler, Hans‐Joachim Wilke, more

Journal of Orthopaedic Research® > 30 > 1 > 112 - 121

Disc degeneration is associated with several changes in the physicochemical environment of intervertebral disc cells. Nucleus pulposus (NP) cells in the center of degenerated discs are exposed to decreased glucose supply, osmolarity, pH, and oxygen levels. To understand the complexity of these interactions on a cellular level, we designed standardized experiments in which we compared responses to...

article

New treatment for peripheral nerve defects: Reconstruction of a 2 cm, monkey median nerve gap by direct lengthening of both nerve stumps

Yuki Hara, Yasumasa Nishiura, Naoyuki Ochiai, Sharula, more

Journal of Orthopaedic Research® > 30 > 1 > 153 - 161

We have developed a new treatment for peripheral nerve defects: nerve‐lengthening method, and confirmed the efficacy and safety of our method using cynomolgus monkeys. A 20‐mm defect in the median nerve of monkey's forearms was repaired through the simultaneous lengthening of both nerve stumps with original nerve‐lengthening device. To evaluate nerve regeneration after neurorrhaphy, electrophysiological,...

article

Identification of a quantitative trait locus for spontaneous osteoarthritis in STR/ort mice

Ken Watanabe, Yasuhiro Oue, Yoshinari Miyamoto, Makiko Matsuura, more

Journal of Orthopaedic Research® > 30 > 1 > 15 - 20

Osteoarthritis (OA) is the most common joint disorder in humans. Most of the animal models of OA were developed by surgical destabilization of joints or through transgenic approaches, and information from naturally occurring models of OA is very limited. The mouse strain STR/ort is recognized as a spontaneous model of OA. This mouse is unique in that it develops late onset cartilage degeneration of...

article

Lower limb kinematic alterations during drop vertical jumps in female athletes who have undergone anterior cruciate ligament reconstruction

Eamonn Delahunt, Lauren Sweeney, Mark Chawke, Judy Kelleher, more

Journal of Orthopaedic Research® > 30 > 1 > 72 - 78

The aim of this study was to determine if anterior cruciate ligament reconstructed (ACL‐R) female athletes exhibit altered lower limb kinematic profiles during jump landing when compared to a non‐injured age, sex, and activity matched control group. Fourteen ACL‐R and 14 non‐injured control subjects performed 3 vertical drop jump (DVJ) trials. Lower limb kinematics were recorded at 200 Hz. Peak and...

article

Effects of age and platelet‐rich plasma on ACL cell viability and collagen gene expression

Mingyu Cheng, Victor M. Johnson, Martha M. Murray

Journal of Orthopaedic Research® > 30 > 1 > 79 - 85

Platelet‐rich plasma (PRP) has shown in vivo potential to stimulate anterior cruciate ligament (ACL) healing at early time points in large animal models. However, in animal models, the healing potential of the ACL is dependent on animal age. In this study, we hypothesized that there are age‐dependent differences in ACL cell metabolism, collagen gene expression, and the ability of the cells to respond...

article

Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis type 1

Junrong Ma, Mi Li, Janet Hock, Xijie Yu

Journal of Orthopaedic Research® > 30 > 1 > 144 - 152

Individuals with nerofibromatosis Type 1 (NF1) frequently suffer a spectrum of bone pathologies, such as abnormal skeletal development (scoliosis, congenital bowing, and congenital pseudoarthroses, etc), lower bone mineral density with increased fracture risk. These skeletal problems may result, in part, from abnormal osteoclastogenesis. Enhanced RAS/PI3K activity has been reported to contribute to...

article

Comparison of osmotic swelling influences on meniscal fibrocartilage and articular cartilage tissue mechanics in compression and shear

An M. Nguyen, Marc E. Levenston

Journal of Orthopaedic Research® > 30 > 1 > 95 - 102

Although the contribution of the circumferential collagen bundles to the anisotropic tensile stiffness of meniscal tissue has been well described, the implications of interactions between tissue components for other mechanical properties have not been as widely examined. This study compared the effects of the proteoglycan‐associated osmotic swelling stress on meniscal fibrocartilage and articular...

article

Low intensity pulsed ultrasound enhances fracture healing in both ovariectomy‐induced osteoporotic and age‐matched normal bones

Wing‐Hoi Cheung, Wai‐Ching Chin, Ling Qin, Kwok‐Sui Leung

Journal of Orthopaedic Research® > 30 > 1 > 129 - 136

Low intensity pulsed ultrasound (LIPUS) was proven to enhance fracture healing effectively. Similar effect of LIPUS on accelerating the osteoporotic fracture healing was therefore hypothesized. The normal and osteoporotic fracture healings under this non‐invasive biophysical intervention of LIPUS were compared and investigated. Closed femoral fracture procedures were performed on 120 Sprague–Dawley...

article

BMP‐2 mediates PGE₂‐induced reduction of proliferation and osteogenic differentiation of human tendon stem cells

Jianying Zhang, James H‐C. Wang

Journal of Orthopaedic Research® > 30 > 1 > 47 - 52

Tendon stem cells (TSCs) have been proposed to play a major role in the development of tendinopathy, which refers to pathological changes, such as calcification, in affected tendons. Using a human TSC (hTSC) culture model, this study investigated the effects of PGE₂, an inflammatory mediator present in injured tendons, on hTSC proliferation and differentiation as well as the molecular mediator for...

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Keywords

OSTEOARTHRITIS (27)
BIOMECHANICS (13)
FRACTURE HEALING (11)
CARTILAGE (9)
COLLAGEN (8)
OSTEOPOROSIS (8)
TENDON (8)
TISSUE ENGINEERING (8)
APOPTOSIS (7)
FINITE ELEMENT ANALYSIS (7)
KNEE (7)
CHONDROGENESIS (6)
DIFFERENTIATION (6)
MENISCUS (6)
MESENCHYMAL STEM CELL (6)
TOTAL HIP ARTHROPLASTY (6)
AGGRECAN (5)
ARTHROPLASTY (5)
CARPAL TUNNEL (5)
CHONDROCYTE (5)
FINITE ELEMENT (5)
INFECTION (5)
INTERVERTEBRAL DISC (5)
MESENCHYMAL STEM CELLS (5)
OSTEOGENESIS (5)
OSTEOSARCOMA (5)
SHOULDER (5)
TOTAL KNEE ARTHROPLASTY (5)
AGING (4)
ANGIOGENESIS (4)
ANIMAL MODEL (4)
ANTERIOR CRUCIATE LIGAMENT (4)
ARTICULAR CARTILAGE (4)
BONE (4)
DISC DEGENERATION (4)
EXTRACELLULAR MATRIX (4)
GROWTH FACTORS (4)
OSSEOINTEGRATION (4)
OSTEOBLAST (4)
PAIN (4)
PROLIFERATION (4)
VEGF (4)
ADAMTS (3)
BIOMECHANICAL PROPERTIES (3)
BMP‐2 (3)
CANINE (3)
CYTOSKELETON (3)
FRACTURE (3)
GAIT ANALYSIS (3)
GROWTH PLATE (3)
HEALING (3)
HIP (3)
INFLAMMATION (3)
KINEMATICS (3)
MRI (3)
MURINE (3)
MUSCULOSKELETAL MODELING (3)
OXIDATIVE STRESS (3)
PATELLOFEMORAL PAIN (3)
RABBIT (3)
RANKL (3)
ROTATOR CUFF (3)
SUBSYNOVIAL CONNECTIVE TISSUE (3)
TENDINOPATHY (3)
TENDON REPAIR (3)
VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) (3)
WEAR (3)
ADOLESCENT IDIOPATHIC SCOLIOSIS (2)
ARTICULAR CHONDROCYTES (2)
ASEPTIC LOOSENING (2)
BIOMARKERS (2)
BONE BIOLOGY (2)
BONE CEMENT (2)
BONE DEFECT (2)
BONE FORMATION (2)
BONE LOSS (2)
BONE REPAIR (2)
BONE TISSUE ENGINEERING (2)
CALCIUM SIGNALING (2)
CANCER (2)
CARPAL TUNNEL SYNDROME (2)
CARTILAGE DEGENERATION (2)
CARTILAGE REGENERATION (2)
CELL ADHESION (2)
CELL PROLIFERATION (2)
CELL THERAPY (2)
DENERVATION (2)
DISTRACTION OSTEOGENESIS (2)
ELECTROMYOGRAPHY (2)
FAILURE (2)
FASCIA LATA ECM (2)
FEMORAL HEAD (2)
FRACTURE RISK (2)
GENDER (2)
GENE EXPRESSION (2)
GENE THERAPY (2)
GENETICS (2)
HIP PROSTHESIS (2)
HOST RESPONSE (2)
HUMAN (2)
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INFONA - science communication portal

Journal of Orthopaedic Research®

Growth potential of different zones of the growth plate—an experimental study in rabbits

Association between measures of trochlear morphology and structural features of patellofemoral joint osteoarthritis on MRI: The MOST study

Vascular endothelial growth factor polymorphisms in patients with steroid‐induced femoral head osteonecrosis

Alterations of overused supraspinatus tendon: A possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology

Effects of aging and degeneration on the human intervertebral disc during the diurnal cycle: A finite element study

Effect of anterior cruciate healing on the uninjured ligament insertion site

Three‐dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model

Migration responses of outer and inner meniscus cells to applied direct current electric fields

The (−1486T/C) promoter polymorphism of the TLR‐9 gene is associated with end‐stage knee osteoarthritis in a Chinese population

The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full‐length injury in the murine patellar tendon

Normal shoulder muscular activation and co‐ordination during a shoulder elevation task based on activities of daily living: An electromyographic study

Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells

New treatment for peripheral nerve defects: Reconstruction of a 2 cm, monkey median nerve gap by direct lengthening of both nerve stumps

Identification of a quantitative trait locus for spontaneous osteoarthritis in STR/ort mice

Lower limb kinematic alterations during drop vertical jumps in female athletes who have undergone anterior cruciate ligament reconstruction

Effects of age and platelet‐rich plasma on ACL cell viability and collagen gene expression

Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis type 1

Comparison of osmotic swelling influences on meniscal fibrocartilage and articular cartilage tissue mechanics in compression and shear

Low intensity pulsed ultrasound enhances fracture healing in both ovariectomy‐induced osteoporotic and age‐matched normal bones

BMP‐2 mediates PGE₂‐induced reduction of proliferation and osteogenic differentiation of human tendon stem cells

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