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In utero exposure of the female foetus to androgens during development disrupts the reproductive axis and results in hypersecretion of luteinising hormone (LH) (but not follicle‐stimulating hormone) in postnatal life. Abnormalities in the neural circuits controlling hypothalamic gonadotrophin‐releasing hormone have been documented; however, androgens could also programme abnormalities in the pituitary...
Gonadotrophin‐releasing hormone (GnRH) regulates reproduction via binding a G‐protein coupled receptor on the surface of the gonadotroph, through which it transmits signals, mostly via the mitogen‐activated protein (MAPK) cascade, to increase synthesis of the gonadotrophin hormones: luteinising hormone (LH) and follicle‐stimulating hormone (FSH). Activation of the MAPK cascade requires an elevation...
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