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P‐glycoprotein (P‐gp), an efflux transporter localised in the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system. Whether it is also implemented in the transport of the endogenous glucocorticoid corticosterone is a matter of debate. The P‐gp knockout mouse model [abcb1a/b (−/−)] has been shown to differ in the functioning of the hypothalamic‐pituitary adrenal...
The multidrug resistance transporter, P‐glycoprotein (P‐gp), contributes to highly lipophilic molecules penetrating the brain from the blood at a much lower rate than expected, and has numerous substrates, inhibitors and modulators. The drug‐transporting isoform of P‐gp is coded by a single human gene, ABCB1, and shares 80% homology with the murine drug‐transporting isoforms, abcb1a and abcb1b, which...
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