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Neurodegeneration, a term that refers to the progressive loss of structure and function of neurons, is a feature of many neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). There is no cure or treatment available that can prevent or reverse neurodegenerative...
TAR DNA‐binding protein 43 (TDP‐43) is an RNA‐binding protein and a major component of protein aggregates found in amyotrophic lateral sclerosis and several other neurodegenerative diseases. TDP‐43 exists as a full‐length protein and as two shorter forms of 25 and 35 kDa. Full‐length mutant TDP‐43s found in amyotrophic lateral sclerosis patients re‐localize from the nucleus to the cytoplasm and in...
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