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J. Neurochem. (2010) 113, 1092–1100.
AbstractAmyotrophic lateral sclerosis is a progressively paralytic neurodegenerative disease that can be caused by mutations in Cu,Zn‐superoxide dismutase 1 (SOD1). Transgenic mice that over‐express mutant SOD1 develop paralysis and accumulate aggregates of mutant protein in the brainstem and spinal cord. The present study uses a cell culture model to demonstrate...
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