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J. Neurochem. (2011) 118, 760–772.
AbstractNitric oxide (NO) has been proposed to down‐regulate NMDA receptors (NMDA‐Rs) in a homeostatic manner. However, NMDA‐R‐dependent NO synthesis also can cause excitotoxic cell death. Using bicuculline‐stimulated hippocampal and cortical cell cultures, we have addressed the role of the brain‐derived neurotrophic factor‐NO pathway in NMDA‐R down‐regulation....
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