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J. Neurochem. (2010) 113, 943–951.
AbstractMammalian motor nerve terminals contain hundreds of thousands of synaptic vesicles, but only a fraction of these vesicles is immediately available for release, the remainder forming a reserve pool. The supply of vesicles is replenished through endocytosis, and newly formed vesicles are refilled with acetylcholine through a process that depends on the vesicular...
J. Neurochem. (2010) 115, 984–993.
AbstractVesicular acetylcholine transporter (VAChT; TC 2.A.1.2.13) mediates storage of acetylcholine (ACh) by synaptic vesicles. A three‐dimensional homology model of VAChT is available, but the binding sites for ACh and the allosteric inhibitor (−)‐trans‐2‐(4‐phenylpiperidino)cyclohexanol (vesamicol) are unknown. In previous work, mutations of invariant W331 in...
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