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The E4 allele of apolipoprotein E (ApoE4) is a key genetic risk factor for late‐onset Alzheimer's disease (AD), increasing the risk of developing the disease by up to three‐fold. However, the mechanisms by which ApoE4 contributes to AD pathogenesis are poorly understood. Here, we utilize a mouse model expressing either human ApoE3 or human ApoE4 to examine the effects of the E4 allele on a wide range...
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