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Several HIV‐1 subtypes are co‐circulating among various high‐risk groups in China, and an increasing prevalence of CRF01_AE was observed among MSM (men who have sex with men) within recent years. Patients infected with CRF01_AE may experience a more rapid disease progression than patients infected with non‐CRF01_AE; however, the underlying mechanisms remains elusive. HIV‐1 Nef is a multifunctional...
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