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Although not directly cytopathic, hepatitis B and C viruses (HBV and HCV) are responsible for millions of deaths per year, and the aging patient population presents a severe public health challenge. Most cases of acute HCV become chronic, but treatment has become increasingly successful following the development of direct acting antiviral agents. Conversely, most cases of acute HBV are cleared in...
Single nucleotide polymorphisms (SNPs) within or near interferon lambda 4 (IFNL4) gene located upstream of IFNL3 are associated with response to anti‐HCV therapy both in interferon (IFN)‐based and IFN‐free regimens. IFNL4 encodes IFNλ4, a newly discovered type III IFN, and its expression is controlled by rs368234815‐TT/ΔG, which is in strong linkage disequilibrium (LD) with other tag SNPs within...
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