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As part of a program toward making analogues of amlexanox (1), currently under clinical investigation for the treatment of type 2 diabetes and obesity, we have synthesized derivative 5 in which deuterium has been introduced into two sites of metabolism on the C‐7 isopropyl function of amlexanox. The synthesis of 5 was completed in an efficient three‐step process utilizing reduction of key olefin 7b...
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