Journal of the European Academy of Dermatology and Venereology
Treatment of severe or recalcitrant plaque psoriasis with traditional systemic therapies may be limited by efficacy or safety/tolerability considerations. The latest information on the pathophysiology of psoriasis and its targeted treatment with biological therapy points to an emerging new treatment paradigm: continuous and earlier systemic therapy. However, few comparative trials of systemic treatments...
Recent research has identified the importance of interleukin 12 (IL)‐12 and IL‐23 in the immunopathogenesis of psoriasis. The p40 subunit common to IL‐12 and IL‐23 is an attractive target for selective therapy. Clinical study data are available for two anti‐IL‐12/23 therapies: ustekinumab (CNTO 1275, approved in 2009 for treatment of plaque psoriasis) and ABT‐874. The Phase 3 clinical trials PHOENIX...
For many years, psoriasis was firmly believed to be a disease of epidermal keratinocytes, but now is attributed to a combination of genetic and environmental factors that promote a T‐cell mediated immune response in the skin. Psoriasis is now understood to be a systemic T‐cell mediated autoimmune disease with the innate immune system playing an important role. Progress in understanding the pathogenesis...
The correct choice of cosmetic products and cleansers is very important to improve skin hydration, to provide moisturizing benefits and to minimize cutaneous damage caused by surfactants. In fact, surfactants may damage protein structures and solubilize lipids. Soaps, defined as the alkali salts of fatty acids, are the oldest surfactants and are quite aggressive. Syndets (synthetic detergents) vary...
Objective Systemic lupus erythematosus is an autoimmune disease with uncertain prognosis as to the course. The patients need pharmacotherapy all their life. The main aim of this study was to determinate the impact of therapeutic schedules on patients’ quality of life.
Methods The study was performed on 83 patients who were divided into five groups according to methods of treatment used. Quality...
Background In acne vulgaris patients, the presence of a dysregulation of the production of innate and specific antimicrobial peptides has been postulated.
Objective This study aims to determine whether human neutrophil proteins (HNP) 1–3 are expressed in acne patients.
Materials and methods HNP 1–3 expression was investigated in 35 acne patients treated with isotretinoin and in 25 healthy subjects...
Background Lichen sclerosus and lichen planus are chronic inflammatory mucocutaneous disorders that may coexist.
Objective The aim of this study was to estimate the period prevalence of oral lichen planus in a cohort of patients with vulvar lichen sclerosus and to document their clinical characteristics.
Methods We report a series of cases of vulvar lichen sclerosus presenting to two dermatologist‐led...