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The Wnt/β‐catenin pathway is one of the most common pathways dysregulated in breast cancer, and may, therefore, be a potential‐therapeutic target. We have investigated the effects of PNU‐74654 in breast cancer, as a Wnt/β‐catenin inhibitor, either alone or in combination with fluorouracil (5‐FU). PNU‐74654 suppressed cell growth at an IC
50 of 122 ± 0.4 μmol/L and synergistically enhanced the antiproliferative...
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