Knowledge about all possible transition and reaction pathways is important for the description of many processes, such as protein‐folding and complex enzymatic reactions. A new algorithm is proposed by Christoph Grebner et al. on page 1810 to determine such transition routes. The energy minima in the perpendicular (n–1) dimensional hyperplane located between reactant and product states, as illustrated in the cover image, represent traces of possible reaction paths. These are ideal starting points for the identification of several transition routes and intermediate minima. The strength of the new approach is shown in the investigation of transition pathways for Ar12 and Ar13 clusters.