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How p53 participates in acute kidney injury (AKI) progress and what are the underlying mechanisms remain illusive. For this issue, it is important to probe into the role of p53 in cisplatin‐induced AKI. We find that p53 was upregulated in cisplatin‐induced AKI, yet, pifithrin‐α inhibites the p53 expression to attenuated renal injury and cell apoptosis both in vivo cisplatin‐induced AKI mice and in...
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