With the growing demand for e‐learning along with striving for excellence associated with globalization, there are worldwide calls for enhancing and assuring quality in e‐learning, specifically in the context of the developing countries. Such calls for quality enhancement, accountability, added value, value for money, self‐evaluation, and role players' satisfaction in higher education settings cannot go unheeded. Addressing the concerns regarding enhancing and assuring quality in e‐learning, a comprehensive e‐quality framework is developed by taking into account the pros and cons of the previous models, frameworks, and studies of e‐quality. This e‐quality framework offers a structured set of factors and benchmarks as a tool for practical quality work with e‐learning in virtual institutions.