Journal of Biomedical Materials Research Part B: Applied Biomaterials
Physical‐chemical surface modifications represent a formidable tool to drive a suitable cell behavior on materials intended to be used in the biomedical field. Plasma processes are among the more powerful methods utilized to modify the surface of materials without altering their bulk intrinsic properties. In particular, by means of plasma treatment processes it is possible to graft chemical functional...
Porous metals (sintered beads and meshes) have been used for many years for different orthopedic applications. Metal foams have been recently developed. These foams have the advantage of being more porous than the traditional coatings. Their high porosity provides more space for bone ingrowth and mechanical interlocking and presents more surface for implant‐bone contact. The objective of this study...
The resin‐based dental composites commonly used in restorations result in more plaque accumulation than other materials. Bacterial biofilm growth contributes to secondary caries and failure of resin‐based dental composites. Methods to inhibit biofilm growth on dental composites have been sought for several decades. It is demonstrated here that zinc oxide nanoparticles (ZnO‐NPs) blended at 10% (w/w)...
A novel injectable bone cement based on mineralized collagen was reported in this paper. The cement was fabricated by introducing calcium sulfate hemihydrate (CaSO4·1/2H2O, CSH) into nano‐hydroxyapatite/collagen (nHAC). The workability, in vitro degradation, in vitro and in vivo biocompatibility of the cement (nHAC/CSH) were studied. The comparative tests via in vitro and in vivo showed that the nHAC/CSH...
At present, limited functional data exists regarding the application and use of biomechanical and imaging technologies for oral implant osseointegration assessment. The objective of this investigation was to determine the functional apparent moduli (FAMs) that could predict the dynamics of oral implant osseointegration. Using an in vivo dental implant osseous healing model, two FAMs, functional bone...
Synthetic calcium‐deficient apatites (CDA) are structurally similar to biological apatites and are well known as chemical precursors of biphasic calcium phosphates (BCP). BCP are mixtures of hydroxyapatite and β‐tricalcium phosphate and are widely used as bone substitutes in human surgery. Bupivacaine, a local anesthetic, has been loaded onto CDA using isostatic compaction. The purpose of this study...
Wander José da Silva,
Jayampath Seneviratne,
Lakshman Perera Samaranayake,
Altair Antoninha Del Bel Cury
The aim of this study was to evaluate the bioactivity and architecture of Candida albicans biofilms developed on the surface of poly(methyl methacrylate) (PMMA) resin. To do this, surface roughness (SR) and surface free energy of PMMA specimens were measured. Next, the biofilms of two different C. albicans strains (ATCC 90028 and SC5314) were allowed to develop on the PMMA surface and evaluated at...
Implant‐related infections are often devastating situations in orthopaedic trauma surgery particularly if multiresistant bacteria are involved. Protection of the implant surface by an antimicrobial coating exhibiting activity against multiresistant bacterial strains is of high interest. Aim of this study was to investigate the antimicrobial effects of an Ag/SiOxCy plasma polymer coating for fracture...
The growing infection rate by methicillin‐resistant Staphylococcus aureus, especially with bone fracture fixation implants, is a major concern in extremity musculoskeletal wound treatment. This preliminary investigation evaluates the ability of chitosan film to be loaded with daptomycin and vancomycin in the operating room, in situ loading, and applied to musculoskeletal fixation devices to lessen...
A prospective randomized long‐term follow‐up study of bioactive glass (BG)‐S53P4 and autogenous bone (AB) used as bone graft substitutes in benign bone tumor surgery during 1993–1997 was conducted. Twenty‐one patients (11 in the BG group, 10 in the AB group) participated in a 14‐year follow‐up. X‐rays and MRI scans were obtained, and in the BG group, CT scans were also performed. In the BG group,...
Tissue engineering scaffolds produced by electrospinning feature a structural similarity to the natural extracellular matrix. Polymer blending is one of the effective methods to provide new and desirable biocomposites for tissue engineering applications. In this study chitosan was blended with gelatin and the effect of processing parameters of electrospinning and the solution properties of the polymer...
Objectives: To characterize the interaction of 1‐Ethyl‐3‐[3‐dimethylaminopropyl] carbodiimide Hydrochloride (EDC) with dentin matrix and its effect on the resin‐dentin bond. Methods: Changes to the stiffness of demineralized dentin fragments treated with EDC/N‐hydroxysuccinimide (NHS) in different solutions were evaluated at different time points. The resistance against enzymatic degradation was indirectly...
This article investigates a method of modifying and optimizing the biocompatibility of decellularized vascular bioimplants when treated with a specialized, drug eluting coating. For this purpose, we carried out aortic transplantations using a porcine model. Decellularized, cross‐linked aortic grafts were coated with poly(D,L‐lactide) (PDLLA). To this coating, we added the anticoagulant drug lepirudin...
The treatment of peri‐implantitis, which causes tissue deterioration surrounding osseointegrated implants, involves surface decontamination and cleaning. However, chemical cleaning agents may alter the structure of implant surfaces. We investigated three such cleaning solutions. Commercially pure (grade 4) machined titanium discs (CAMLOG Biotechnologies AG, Switzerland) were treated with 3% H2O2 (5...
This study evaluated chlorhexidine release from experimental, chlorhexidine‐incorporated polymethyl methacrylate (PMMA)‐based resin cements prepared from Super‐Bond C&B (Sun Medical) and examined the antimicrobial activity against Streptococcus mutans and Enterococcus faecalis. Chlorhexidine diacetate was added into PMMA polymer to obtain chlorhexidine concentration of 0.0, 1.0, 2.0, 3.0, and...
If endothelial progenitor cells (EPCs), which circulate in blood flow, are captured on the luminal surface of an implanted artificial graft and sooner or later proliferate to form a fully endothelialized surface, such a small‐diameter artificial graft must exhibit a high patency rate. This study aimed at designing a luminal surface of elastomeric electrospun mesh graft, which is capable of selective...
In this article, synthesis and application of calcium phosphate/poly‐DL‐lactide‐co‐glycolide (CP/PLGA) composite biomaterial in particulate form, in which each CP granule/particle is coated with PLGA, are described. Two types of the particulate material having different particle sizes were synthesized: one with an average particle diameter between 150 and 250 μm (micron‐sized particles, MPs) and the...
Our previous studies showed that a mechano‐active scaffold made of poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) exhibited a high potential to realize the formation of a functional, engineered cartilage in vitro. This animal study therefore was designed to investigate the feasibility of repairing on osteochondral defect with the use of bone marrow‐derived mesenchymal stem cells (BMSCs) incorporated with...
This study evaluated the effect of resin monomer composition on crystal growth at the interface between the resin/bioglass composites and water. Light‐cured resin that contained 2‐bis[4(2‐hydroxy‐3‐methacryloyloxy‐propyloxy)‐phenyl], 2‐hydroxyethyl methacrylate, and triethylene glycol dimethacrylate with different compositions were used. Resin/bioglass composites were prepared with 40 mass% bioglass...
The formation of biodegradable implants for use in osteosynthesis has been a major goal of biomaterials research for the past 2–3 decades. Self‐reinforced polylactide systems represent the most significant success of this research to date, however, with elastic constants up to 12–15 GPa at best, they fail to provide the initial stiffness required of devices for stabilizing fractures of major load‐bearing...