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This study describes the synthesis of novel gene delivery vector with low toxicity and high transfection efficiency for magnetofection. The rational design of magnetofection vector called PPMag (PEI‐associated polycaprolactone (PCL)‐SPIONs) composed of oleic acid (OA) stabilized superparamagnetic iron oxide nanoparticles (SPPIONs) prepared by thermolysis of iron oleate with a combination of hydrophobic...
The hydrophobic polyphenol curcumin has anti‐inflammatory, antimicrobial, and wound‐healing properties that warrant its pharmacological consideration. We report a curcumin nanoparticle with a tripolymeric composite that can be used as a delivery device for wound healing. The present composite nanoparticles were prepared with three biocompatible polymers of chitosan, poly‐γ‐glutamic acid, and pluronic...
The effect of kinematics, loading and centre of rotation on the wear of an unconstrained total disc replacement have been investigated using the ISO 18192‐1 standard test as a baseline. Mean volumetric wear rate and surface morphological effects were reported. Changing the phasing of the flexions to create a low (but finite) amount of crossing path motion at the bearing surfaces resulted in a significant...
Glaucoma is the second leading cause of blindness with ∼70 million people worldwide who are blind from this disease. The currently practiced trabeculectomy surgery, the gold standard treatment used to stop the progression of vision loss, is rather draconian, traumatic to the patient and requires much surgical skill to perform. This article summarizes the more than 10‐year development path of a novel...
Corrosion processes of metallic biomaterials in the oral cavity pose a significant limitation to the life and reliable functioning of dental materials. In this article, the influence of environment bacteria Desulfotomaculum nigrificans sulfate reducing bacteria on the corrosion processes of 316LV steel was assessed. After 14 and 28 days of contact of the material with the bacterial environment, the...
The wetting characteristics of self‐assembled monolayers (SAMs) on three different surface structures of thin film, microcone array, and nanowire forest topologies, which were chemically modified using phosphonic acid (HDF‐PA and OD‐PA) and trichlorosilane (HDF‐S), were investigated. The molecular SAM‐coated nanowire forest structures exhibited superhydrophobic properties with contact angles of 150...
Magnesium‐based implants exhibit several advantages, such as biodegradability and possible osteoinductive properties. Whether the degradation may induce cell type‐specific changes in metabolism still remains unclear. To examine the osteoinductivity mechanisms, the reaction of bone‐derived cells (MG63, U2OS, SaoS2, and primary human osteoblasts (OB)) to magnesium (Mg) was determined. Mg‐based extracts...
Bioactivity of multicomponent TiCaPCO(N) and Ag‐doped TiCaPCO(N) films was evaluated in vitro using simulated body fluid (SBF) and compared with that of bioactive glass Biogran. The first group of films was fabricated by magnetron sputtering of composite TiС0.5–Ti3POx–CaO target produced via the self‐propagating high‐temperature synthesis (SHS) method (TiCaPCON films), after which their surface was...
In an attempt to find an ideal closure method during annulus defect repair, we evaluate the use of medical glue by mechanical and biocompatible test. Cyanoacrylate medical glue was applied together with a multilayer microfiber/nanofiber polycaprolactone scaffold and suture in annulus repair. Continuous axial loading and fatigue mechanical test was performed. Furthermore, the in vitro response of mesenchymal...
Calcium phosphates (Ca‐P) are used commonly as artificial bone substitutes to control the biodegradation rate of an implant in the body fluid. This study examined the in vitro proliferation of human bone marrow‐derived mesenchymal stem cells (hBMSCs) on triphasic Ca‐P samples. For this aspect, hydroxyapatite (HA), dicalcium phosphate dehydrate (DCPD), and calcium hydroxide (Ca(OH)2) were mixed at...
Although bioactive glasses are successfully used as bone substitutes, recent studies have revealed that the high alkali content in these glasses leads to fast in vivo degradation rates that may not match the rate of new bone ingrowth. This prompted us to design and develop novel bioactive glasses that are devoid of alkali but still demonstrate high bioactivity in vitro. This article describes the...
Severe osteoporotic diseases, such as Paget's disease, Osteogenesis Imperfecta, and Legg Calve Perthes disease, lack treatments that address the pathobiology of the diseases, as well as, long‐term and prospective studies. Bisphosphonates, which are known to dramatically hinder the viability of osteoclast cells, along with gold nanoparticles (GNP) are a potential theranostic for osteoporotic diseases...
High suture tension is one of the causes for many wound‐healing problems. Constriction of tissue within the suture loops of nonelastic sutures can lead to cutting of the suture through tissues and necrosis of the tissue within these loops. The use of elastic materials in new suture types could give the material the ability to adapt tension to the tissue requirements and subsequently lead to more vital...
This study correlated the refractive indices (RIs) of unfilled resin mixtures and resin‐based composites (RBCs) with color and translucency of conventional and low‐shrinkage RBCs. Unfilled resin mixtures based on different ratios of conventional monomers Bisphenol A‐glycidyl‐methacrylate (BisGMA)/triethyleneglycol‐dimethacrylate (TEGDMA) and urethane‐dimethacrylate (UDMA)/TEGDMA and a low‐shrinkage...
Orthopedic components, such as the acetabular cup in total hip joint replacement, can be fabricated using porous metals, such as titanium, and a number of processes, such as selective laser melting. The issue of how to effectively remove loose powder from the pores (residual powder) of such components has not been addressed in the literature. In this work, we investigated the feasibility of two processes,...
The sustained release of ophthalmic therapeutics to the posterior segment of the eye is a challenge. Injectable polymer materials have the potential to reduce injection frequency by providing long term therapeutic delivery. Copolymers with varying N‐isopropylacrylamide, acrylamide (AAm), acrylic acid N‐hydroxysuccinimide, and (r)‐α‐acryloyloxy‐β,β‐dimethyl‐γ‐butyrolactone (DBA) were synthesized by...
This study evaluated the effects of the Biosilicate® and poly (D,L‐lactic‐co‐glycolic) acid composites on bone repair in a tibial bone defect model in rats by means of using histological evaluation (histopathological and morphometric analysis) and gene expression analysis. Eighty male Wistar rats (12 weeks old, weighing ±300 g) were randomly divided into two groups: Biosilicate® group (BG) and Biosilicate...
Self‐assembly technique was applied to introduce functional groups and form hydroxyl‐, amine‐, and carboxyl‐terminal self‐assembled monolayers (SAMs). The SAMs were grafted onto titanium substrates to obtain a molecularly smooth functional surface. Subsequent hydrothermal crystal growth formed homogeneous and crack‐free crystalline hydroxyapatite (HA) coatings on these substrates. AFM and XPS were...
Antimicrobial coating of polyethylene endotracheal tubes (PE ETTs) has proven to be an effective method to prevent endoluminal biofilm formation. A transparent silicon‐modified antimicrobial PE ETT was obtained by coating PE with a SiO2/γ‐methacryloxypropyl trimethoxy silane (KH‐570)/methyltriethoxysilane (MTES)/Ag‐SiO2 solution prepared by chemically mixing Ag‐SiO2 with SiO2/KH‐570/MTES in solution...
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