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This work investigated the effect of N‐acetylcysteine (NAC), on renal hemodynamics in cisplatin (CP)‐induced nephrotoxicity in Wistar–Kyoto (WKY) rats. The animals were divided into four groups (n = 5 or 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) N‐acetylcysteine (500 mg kg−1 per day for 9 days), respectively. The third and fourth groups were given...
Limited experimental models exist to assess drug toxicity in pediatric populations. We recently reported how a multi‐age rat model could be used for pre‐clinical studies of comparative drug toxicity in pediatric populations. The objective of this study was to expand the utility of this animal model, which previously demonstrated an age‐dependent sensitivity to the classic nephrotoxic compound, gentamicin,...
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