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Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes and the inflammatory cytokine expression in male F344 rats. Exposure of animals to AFB1 [5–75 µg kg–1 body weight (BW)] for 1 week showed dose‐dependent decreases in the percentage of splenic CD8+ T cells and CD3‐CD8a+ NK cells...
The present study was designed to investigate genotoxic and cytotoxic effects and oxidative damage of increasing concentrations of nano‐hydroxyapatite (5, 10, 20, 50, 75, 100, 150, 300, 500 and 1000 ppm) in primary human blood cell cultures. Cell viability was detected by [3‐(4,5‐dimethyl‐thiazol‐2‐yl) 2,5‐diphenyltetrazolium bromide] assay and lactate dehydrogenase release, while total antioxidant...
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