While the stigma surrounding mental illness has been well‐established, less is known about methods for reducing that bias. In both laboratory (Study 1) and community (Study 2) samples, we tested the efficacy of imagined contact and perspective‐taking for reducing stigma against depression. Participants first read a vignette about an individual with depression and then imagined either interacting with the individual (imagined contact), putting themselves in the individual's shoes (perspective‐taking) or a neutral scene (control). In both samples, imagined contact was more effective in reducing stigma against depression than perspective‐taking. The findings suggest that different prejudice reduction strategies should be used for different stigmatized groups.