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Tag7 (PGRP‐S or PGLYRP1), while possessing an antimicrobial activity, also exhibits an antitumor effect when in complex with the major heat shock protein Hsp70. The cytotoxic Tag7‐Hsp70 complex is secreted by lymphocytes after interaction with the HLA‐negative tumors. Previously, we have shown that IL‐2 induces formation of the CD4+ and CD8+ cytotoxic subpopulations of human lymphocytes, which kill...
The innate immunity protein Tag7 (PGRP‐S, PGLYRP1) is involved in antimicrobial and antitumor defense. As shown in our previous studies, Tag7 specifically interacts with the major heat shock protein Hsp70 to form a stable Tag7–Hsp70 complex with cytotoxic activity against tumor cells. A stable complex of Tag7 with the calcium‐binding protein Mts1 (S100A4) stimulates migration of lymphocytes. Moreover,...
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