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Extracellular matrix (ECM)‐independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial–mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM‐independent survival, EMT, and migration in MCF10A cells. TP53I11 has long been considered as a transcriptional target...
Osteoarthritis (OA) is a common age‐related disorder. Chondrocytes in joint tissue play a critical role in normal articular cartilage function and tissue homeostasis. Local inflammatory cytokine‐induced chondrocyte senescence contributes to the development and progression of OA. Various dipeptidyl peptidase‐4 (DPP‐4) inhibitors have been widely used to treat type 2 diabetes. Here, we report a novel...
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