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The SARS‐CoV‐2 makes its way into the cell via the ACE2 receptor and the proteolytic action of TMPRSS2. In response to the SARS‐CoV‐2 infection, the innate immune response is the first line of defense, triggering multiple signaling pathways to produce interferons, pro‐inflammatory cytokines and chemokines, and initiating the adaptive immune response against the virus. Unsurprisingly, the virus has...
SARS‐CoV‐2, the causing agent of the ongoing COVID‐19 pandemic, is a beta‐coronavirus which has 80% genetic homology with SARS‐CoV, but displays increased virulence and transmissibility. Initially, SARS‐CoV‐2 was considered a respiratory virus generally causing a mild disease, only severe and fatal in the elderly and individuals with underlying conditions. Severe illnesses and fatalities were attributed...
Novel SARS‐CoV‐2 named due to its close homology with severe acute respiratory syndrome coronavirus (SARS‐CoV) is the etiologic agent for the ongoing pandemic outbreak causing loss of life and severe economic burden globally. The virus is believed to be evolved in a recombined form of bat and animal coronavirus with the capacity to infect human host using the ACE2 receptors as an entry point. Though...
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