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Allogeneic CD8+ cytotoxic T cells play an essential role in rejecting transplanted allografts, but how their effector function is regulated on a transcriptional level remains unclear. Herein, we investigate the role of interferon regulatory factor 4 (IRF4) in controlling CD8+ T‐cell function in response to transplant. B6.Rag1−/− mice were adoptively transferred with CD8+ T cells isolated from either...
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