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T‐cell recognition of MHC–peptide complexes shows a high degree of polyspecificity extending to recognition of a large number of structurally unrelated peptides. Examples of polyspecificity reported to date are confined to recognition of epitopes from distinct proteins or synthetic peptide libraries. Here we describe intramolecular polyspecificity of CD4 T cells specific for several epitopes within...
VGX‐1027 [(S,R)‐3‐phenyl‐4,5‐dihydro‐5‐isoxasole acetic acid] is a small molecule compound with immunomodulatory properties, which favourably influences the development of immuno‐inflammatory and autoimmune diseases in different animal models such as type 1 diabetes mellitus, pleurisy, rheumatoid arthritis and inflammatory bowel disease. However, the precise mechanism of action of VGX‐1027 remains...
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