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Benign familial neonatal seizures (BFNS) are a dominant epilepsy syndrome caused by mutations in the voltage‐gated potassium channels KV7.2 and KV7.3. We examined the molecular pathomechanism of a BFNS‐causing mutation (p.N258S) in the extracellular S5‐H5 loop of KV7.2. Wild type (WT) and mutant channels, expressed in both Xenopus laevis oocytes and CHO cells, were studied using electrophysiological...
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