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Aims: Laparoscopic distal pancreatectomy is becoming a more commonly used procedure, which may involve the use of four to seven ports, depending on the technique. Initial data on feasibility, safety and outcome with the three‐port laparoscopic distal pancreatectomy are presented.
Methods: The patient is placed in a partial thoracoabdominal position exposing the left flank in a reverse Trendelenberg...
Objectives: Resection of colorectal cancer (CRC) liver metastases (LM) in pathological liver (PL) patients (with cirrhosis or hepatopathy) is extremely rare. The aim of this study was to perform a multicentre, retrospective analysis of epidemiology, surgical techniques and outcomes in patients with PL who underwent hepatic resection for CRC‐LM.
Methods: A retrospective, multicentre questionnaire...
Introduction: Multiple organ dysfunction is the main cause of death in severe acute pancreatitis. Primary mitochondrial dysfunction plays a central role in the development and progression of organ failure in critical illness. The present study investigated mitochondrial function in seven tissues during early experimental acute pancreatitis.
Methods: Twenty‐eight male Wistar rats (463 ± 2 g; mean...
Background: Patients with familial adenomatous polyposis (FAP) develop duodenal and ampullary polyps that may progress to malignancy via the adenoma–carcinoma sequence.
Objective: The aim of this study was to review a large series of FAP patients undergoing pancreaticoduodenectomy for advanced duodenal and ampullary polyposis.
Methods: A retrospective case notes review of all FAP patients undergoing...
Objectives: Non‐operative management has become the treatment of choice in the majority of liver injuries. The aim of this study was to assess the changes in primary treatment and outcomes in a single Dutch Level 1 trauma centre with wide experience in angio‐embolisation (AE).
Methods: The prospective trauma registry was retrospectively analysed for 7‐year periods before (Period 1) and after (Period...
Background: Cholangiocarcinoma (CC) is a rare tumour with a dismal prognosis. As conventional medical management offers minimal survival benefit, surgery currently represents the only chance of cure. We evaluated DNA copy number (CN) alterations in CC to identify novel therapeutic targets.
Methods: DNA was extracted from 32 CC samples. Bacterial artificial chromosome (BAC) array comparative genomic...
Background: Plasma interleukin‐6 (IL‐6) levels increase during liver resection. The source of this IL‐6 is hitherto unclear. It has been demonstrated that the hepatosplanchnic area takes up IL‐6 but the role of the gut and liver is unknown. The aim of the present study was to investigate the role of the gut and liver in IL‐6 homeostasis during liver surgery.
Methods: Before and after partial hepatectomy,...
Background: Biliary complications following liver transplantation result in major morbidity. We undertook a 10‐year audit of the incidence, management and outcomes of post‐transplant biliary complications at the New Zealand Liver Transplant Unit.
Methods: Prospectively collected data on 348 consecutive liver transplants performed between February 1998 and October 2008 were reviewed. The minimum...
Background: Cholangiocarcinoma (CC) is a fatal malignancy, the incidence of which is increasing worldwide, with substantial regional variation. Current diagnostic techniques to distinguish benign from malignant biliary disease are unsatisfactory. Metabolic profiling of bile may help to differentiate benign from malignant disease. No previous studies have compared the metabolic profiles of bile from...
Introduction: Microwave ablation (MWA) uses non‐ionising thermal energy to cause cell death by coagulative necrosis. Colour Doppler ultrasound (US) produces a spherical image during tissue ablation that appears to approximate the microwave near field (MNF) in shape and size. The aim of the present study was to determine whether colour Doppler US images observed during microwave ablation correlate...
Background: Epigenetics is a rapidly evolving field of genetic study applicable to nearly every aspect of genome‐related research. The importance of epigenetics has been recognised in human hepatocellular carcinoma (HCC). Changes in DNA methylation patterns, including global hypomethylation and promoter hypermethylation, are thought to be early events in hepatocarcinogenesis.
Objectives: This review...
Background: Increased visceral fat and pancreatic steatosis promote lymphatic metastases and decreased survival in patients with pancreatic adenocarcinoma after pancreatoduodenectomy (PD).
Objectives: We aim to determine the utility of preoperative computed tomography (CT) measurements of pancreatic steatosis and visceral fat as prognostic indicators in patients with pancreatic adenocarcinoma.
Methods: ...
Background: An important issue in the transplantation of livers procured from cardiac death donors (CDDs) concerns why some centres report equivalent outcomes and others report inferior outcomes in transplantations using CDD organs compared with standard criteria donor (SCD) organs. Resolving this discrepancy may increase the number of usable organs.
Objectives: This study aimed to test whether...
Background: Macrovesicular steatosis is assumed to be an important risk factor for early allograft dysfunction (EAD) after orthotopic liver transplantation (OLT).
Aim: To evaluate the impact of steatosis in combination with other risk factors on the outcome of OLT.
Methods: The degree of steatosis was analysed in 165 consecutive OLTs and was classified by histological examination as non (M0), mild...
Pancreaticoduodenectomy is one of the most challenging surgical procedures which requires the highest level of surgical expertise. This procedure has constantly evolved over the years through the meticulous efforts of a number of surgeons before reaching its current state. This review navigates through some of the early limitations and misconceptions and highlights the initial milestones which laid...
Objective: To evaluate any change in the operative and survival outcomes in patients undergoing a right hepatectomy after adoption of the no‐clamp technique using a radiofrequency dissecting sealer (TissueLink™) in liver resection.
Methods: In all, 58 consecutive patients who underwent a right hepatectomy from July 2003 to December 2007 (Group 1) were compared with 66 consecutive patients who underwent...
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