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ObjectivesTreatment simplification involving induction with a ritonavir (RTV)‐boosted protease inhibitor (PI) replaced by a nonboosted PI (i.e. atazanavir) has been shown to be a viable option for long‐term antiretroviral therapy. To evaluate the clinical evidence for this approach, we conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) evaluating efficacy and safety...
ObjectivesRitonavir‐boosted atazanavir and darunavir are protease inhibitors that are recommended for initial treatment of HIV infection because each has shown better lipid effects and overall tolerability than ritonavir‐boosted lopinavir. The extent to which lipid effects and overall tolerability differ between treatments with atazanavir and darunavir and whether atazanavir‐induced hyperbilirubinaemia...
ObjectivesPregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the risk of vertical transmission. Here we describe atazanavir/ritonavir (ATV/r) plasma concentrations in a cohort of pregnant women undergoing routine...
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