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Aims
The distinction of high‐grade prostate cancer (PCa) from poorly differentiated urothelial carcinoma (UC) can be somewhat challenging on clinical and morphological grounds alone, yet it is of great importance for prognostication and choice of treatment. GATA3 is a useful immunohistochemical marker to confirm urothelial origin. However, recent works report strong GATA3 immunoexpression in primary...
Tumour grade is a critical prognostic parameter for guiding the management of patients with non‐muscle invasive bladder cancer. In 2004, the World Health Organisation (WHO) adopted a binary (low‐grade/high‐grade) grading system to replace the three‐tier (grades 1–3) system used to grade urothelial carcinoma since 1973. However, there is significant global variation in the grading of urothelial carcinoma...
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