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Learning and memory deficits associated with age‐related mild cognitive impairment have long been attributed to impaired processing within the hippocampus. Hyperactivity within the hippocampal CA3 region that is associated with aging is mediated in part by a loss of functional inhibitory interneurons and thought to underlie impaired performance in spatial memory tasks, including the abnormal tendency...
Despite a growing number of studies showing relationships between behavior and resting‐state functional MRI measures of large‐scale brain network connectivity, no study to our knowledge has sought to investigate whether intrinsic connectivity–behavioral relationships are stable over time. In this study, we investigated the stability of such brain–behavior relationships at two timepoints, approximately...
Memory is a temporally evolving molecular and structural process, which involves changes from local synapses to complex neural networks. There is increasing evidence for an involvement of developmental pathways in regulating synaptic communication in the adult nervous system. Notch signaling has been implicated in memory formation in a variety of species. Nevertheless, the mechanism of Notch in memory...
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