Background
Radiation‐induced salivary gland tumors are well described in the literature, with mucoepidermoid cancer being the most common histologic entity. Epithelial‐myoepithelial carcinoma is a rare tumor accounting for <1% of all tumors in the salivary glands.
Methods and Results
We describe the first case of radiation‐induced epithelial‐myoepithelial carcinoma in the English‐language medical literature. A 48‐year‐old man presented with right‐sided mandibular pain and trismus, 25 years after mantle‐field radiation therapy (RT) for Hodgkin lymphoma. He underwent excision of a right submandibular mass, which revealed a diagnosis of epithelial‐myoepithelial carcinoma. Although typically a low‐grade tumor, the histology revealed extensive necrosis and high mitotic activity. The patient required multiple resections and adjuvant therapy after multiple recurrences over a 4‐year period.
Conclusion
Reports of epithelial‐myoepithelial carcinoma are relatively rare and this case highlights the importance of long‐term follow‐up and increased awareness of the risks of salivary gland tumors in this population. © 2014 Wiley Periodicals, Inc. Head Neck37: E96–E98, 2015