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(Headache 2010;50:99‐168)
Background.— It has been suggested that homocysteine (Hcy) and the 5′‐10′‐methylenetetrahydrofolate reductase (MTHFR) C677T variant are implicated in the pathogenesis of migraine. Homocysteine has the potential to damage endothelium and accelerate atherosclerosis. Genetic factors such as the MTHFR C677T polymorphism, and other polymorphisms in folate‐related genes associated...
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