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Synucleinopathies refer to a range of neurodegenerative diseases caused by abnormal α‐synuclein (α‐Syn) deposition, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Their pathogenesis is strongly linked to microglial dysfunction and neuroinflammation, which involves the leucine‐rich‐repeat kinase 2 (LRRK2)‐regulated nuclear factor of activated...
Nogo‐A, B, and C are well described members of the reticulon family of proteins, most well known for their negative regulatory effects on central nervous system (CNS) neurite outgrowth and repair following injury. Recent research indicates a relationship between Nogo‐proteins and inflammation. Microglia, the brain's immune cells and inflammation‐competent compartment, express Nogo protein, although...
Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response. In recent years, we have a deep understanding of the neural pathways of itch sensation transmission. However, there are few reports on the role of non‐neuronal cells in itch. Microglia are known to play a key role in chronic neuropathic pain and acute inflammatory pain. It...