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The Asia‐Oceanian region is the most populous region in the world. Although there has been substantial economic development and improvement in health services in recent years, epilepsy remains generally an underrecognized and understudied condition. To help promote research in the region, the Commission on Asian and Oceanian Affairs (CAOA) of the International League Against Epilepsy (ILAE) appointed...
Objective
This study examined the influence of seizures, antiepileptic drugs (AEDs), intelligence quotient (IQ), and symptoms of depression and anxiety on health‐related quality of life (HRQOL) 4–11 years after pediatric epilepsy surgery.
Methods
Participants were 109 patients with childhood‐onset intractable epilepsy; 71 had undergone surgery on average 6.9 years before this study. Patients and...
Refractory status epilepticus (RSE) is a medical emergency, with significant morbidity and mortality. The use and effectiveness of clobazam, a unique 1,5‐benzodiazepine, in the management of RSE has not been reported before. Over the last 24 months, we identified 17 patients with RSE who were treated with clobazam in our hospital. Eleven of the 17 patients had prior epilepsy. Fifteen patients had...
Objective
Examine the efficacy of a competitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)/kainate glutamate receptor antagonist, selurampanel (BGG492), in the human photostimulation model.
Methods
Patients with epilepsy and a generalized epileptiform electroencephalography response to intermittent photic stimulation (photoparoxysmal response or PPR; diagnosed ≥6 months prior to...
Objective
To characterize the changes in microglial proinflammatory M1 and antiinflammatory M2 marker expression during epileptogenesis in the chronic pilocarpine and intrahippocampal kainate models.
Methods
M1‐activated microglia express proinflammatory cytokines driving infiltration of cells, whereas M2‐activated microglia are more reparative, promoting phagocytosis of debris and expression of...
Objective
Children with epilepsy (EPI) have a higher rate of attention‐deficit/hyperactivity disorder (ADHD; 28–70%) than typically developing (TD) children (5–10%); however, attention is multidimensional. Thus, we aimed to characterize the profile of attention difficulties in children with epilepsy.
Methods
Seventy‐five children with localization‐related epilepsy ages 6–16 years and 75 age‐matched...
Objective
Electrocorticographic (ECoG) recordings from patients with medically intractable partial‐onset seizures treated with a responsive neurostimulator system (the RNS System) that detects and stores physician‐specified ECoG events provide a new data resource. Interpretation of these recordings has not yet been validated. The purpose was to evaluate the interrater interpretation of chronic ambulatory...
Neuromodulative treatment options are warranted in patients with difficult‐to‐treat epilepsy. However, acquisition of controlled data on deep brain stimulation has so far been achieved only for the centromedian and anterior thalamic nucleus. In a case series of four patients with intractable partial epilepsy, a randomized controlled cross‐over protocol was used to get insight into efficacy and safety...
Objective
Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video–electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization....
Objectives
Valproic acid (VPA)–induced adverse effects, which are sometimes serious in children, can be associated with alterations in VPA metabolism. VPA‐evoked toxicity is attributed to both the parent compound and its unsaturated metabolites, primarily formed by the cytochrome P450 (CYP)2C9 enzyme. Thus, patients’ CYP2C9‐status may account for the predisposition to adverse reactions, and testing...
Objective
Continuous electroencephalography (cEEG) is important for treatment guidance in status epilepticus (SE) management, but its role in clinical outcome prediction is unclear. Our aim is to determine which cEEG features give independent outcome information after correction for clinical predictor.
Methods
cEEG data of 120 consecutive adult patients with SE were prospectively collected in three...
People with Alzheimer's disease (AD) are up to 10 times more likely to develop epilepsy than the age‐matched general population. However, given that only a proportion of patients with AD develop epilepsy, it is likely that additional factors may be required for the epilepsy to emerge. This study aimed to better understand the relationship between AD pathology and seizure susceptibility. It also aimed...
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