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ObjectiveTo assess symptoms of attention‐deficit/hyperactivity disorder (ADHD) and their impact among adults with epilepsy from a large community‐based survey.
MethodsAdults who self‐reported epilepsy were sent a postal survey including the Adult ADHD Self‐Report Scale version 6 (ASRS‐6), Physicians Health Questionnaire (PHQ‐9), Generalized Anxiety Disorder Assessment 7 (GAD‐7), and questions about...
ObjectivesAutobiographic memory encompasses the encoding and retrieval of episodes, people, and places encountered in everyday life. It can be impaired in both epilepsy and frontal lobe damage. Here, we performed an initial investigation of how autobiographic memory is impacted by chronic frontal lobe epilepsy (FLE) together with its underlying pathology.
MethodWe prospectively studied a series of...
ObjectivesTo quantify the life expectancy of surgically eligible children with refractory epilepsy comparing two treatment strategies: medical treatment only versus epilepsy surgery.
MethodsDecision analysis model populated with available parameters from the literature. One‐ and two‐way sensitivity analyses and second‐order Monte Carlo simulations evaluated the robustness of the results across wide...
ObjectiveTo examine the effectiveness of intramuscular (IM) midazolam versus intravenous (IV) lorazepam for the treatment of pediatric patients with status epilepticus (SE) in the prehospital care setting.
MethodsThis multicenter clinical trial randomized patients diagnosed with SE to receive either IM midazolam or IV lorazepam administered by paramedics in the prehospital care setting. Included...
ObjectiveThere is increasing evidence that epileptic activity involves widespread brain networks rather than single sources and that these networks contribute to interictal brain dysfunction. We investigated the fast‐varying behavior of epileptic networks during interictal spikes in right and left temporal lobe epilepsy (RTLE and LTLE) at a whole‐brain scale using directed connectivity.
MethodsIn...
ObjectiveInterictal high frequency oscillations (HFOs) are a promising candidate as a biomarker in epilepsy as well as for defining the seizure‐onset zone as for the prediction of the surgical outcome after epilepsy surgery. The purpose of the study is to investigate properties of HFOs in long‐term recordings with respect to the sleep–wake cycle and anatomic regions to verify previous results based...
ObjectiveScreening for specific coding mutations in the EFHC1 gene has been proposed as a means of assessing susceptibility to juvenile myoclonic epilepsy (JME). To clarify the role of these mutations, especially those reported to be highly penetrant, we sought to measure the frequency of exonic EFHC1 mutations across multiple population samples.
MethodsTo find and test variants of large effect,...
ObjectiveUsing a hypothesis‐driven approach, subcortical and cortical regions implicated in anxiety disorders in the general population were examined in children with recent‐onset epilepsy with versus without anxiety compared to controls. This study reports frequency of anxiety disorders while examining familial, clinical, and demographic variables associated with anxiety in children with epilepsy...
ObjectiveTo develop a better understanding of mechanisms of seizures and long‐term epileptogenesis using neurocysticercosis.
MethodsA workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.
ResultsHuman neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating...
ObjectiveFrom July to August 2014, Epilepsia conducted an online survey seeking opinions that explained the discrepancy between the incidence and prevalence of epilepsy in lower income countries. Data on cumulative incidence suggest a higher rate of active epilepsy than reported in lifetime prevalence surveys. This study reports the findings of that poll addressing the proposal in our Controversy...
ObjectiveA common rodent model in epilepsy research employs the muscarinic acetylcholine receptor (mAChR) agonist pilocarpine, yet the mechanisms underlying the induction of pilocarpine‐induced seizures (PISs) remain unclear. Global M1mAChR (M1R) knockout mice are resistant to PISs, implying that M1R activation disrupts excitation/inhibition balance. Parvalbumin‐positive (PV) inhibitory neurons express...
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