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Recent data suggest that neuronal necrosis plays a prominent role in neuronal injury following status epilepticus (SE), even in the immature brain. We review the evidence that SE‐induced neuronal necrosis is an active form of death involving caspases and mitochondrial death factors. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL,...
We review the experimental evidence from animal models that suggest that brief, evoked seizures can result in neuronal death while spontaneous seizures normally do not, as well as human data showing damage may progress in certain patients, and we describe the cell death and survival pathways regulating these processes. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition...
Aberrant sprouting of granule cell axons is a common feature in temporal lobe epilepsy. An increasingly detailed picture of granule cell circuit changes has emerged, but the cause–effect relationship between mossy fiber sprouting and epileptogenesis remains unclear. Recent progress in suppressing mossy fiber sprouting might help address its functional consequences. For an expanded treatment of this...
Epilepsy is common following various brain insults. We review experimental and clinical data supporting the involvement of a primary blood–brain barrier (BBB) injury in seizures and epileptogenesis. These data point to novel signaling cascades, which may offer new therapeutic targets for the prevention and treatment of epilepsy. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies...
Development of new excitatory connectivity and decreases in γ‐aminobutyric acid (GABA)ergic inhibition are mechanisms underlying posttraumatic epileptogenesis in animal models. Experimental strategies that interfere with these processes, applied between the trauma and seizure onset, are antiepileptogenic in the laboratory, and have promise for prophylaxis of epileptogenesis after cortical injury in...
Recent evidence in humans and in experimental animal models indicates that epileptiform interictal events in partial epileptic disorders show a variety of different features. Cellular, network, and pharmacologic mechanisms that underlie interictal events are here reviewed, with particular attention to their relation with ictal activity. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition...
The γ‐aminobutyric acid (GABA)B receptor (GABABR) is a 7‐transmembrane G protein–coupled receptor for GABA, the major inhibitory neurotransmitter in brain. The pathophysiology of typical absence seizures with normal cognitive development and atypical absence seizures associated with severe impairment in cognition (Models of Seizures and Epilepsy, Elsevier Academic Press, San Diego, 2006) involves...
New evidence indicates that increased, rather than decreased, γ‐aminobutyric acid (GABA)ergic inhibition characterizes typical absence seizures. In particular, enhanced tonic GABAA inhibition, resulting from a malfunction of the astrocytic GABA transporter GAT‐1, occurs in thalamocortical neurons of all well‐established pharmacologic and genetic models. Interestingly, GABAB receptors positively modulate...
Adeno‐associated virus (AAV)–mediated neuropeptide Y (NPY) overexpression in areas of seizure onset or generalization may be effective for the treatment of pharmacoresistant seizures in focal onset epilepsy. NPY overexpression mediates anticonvulsant activity in various seizures models and antiepileptogenic effects in kindling. Side effects are limited thus suggesting that this therapeutic approach...
Cell transplantation may repair neural circuits in the epileptic brain. Grafted cells should disperse, migrate, and functionally integrate. Generation of inhibitory interneurons with these abilities could be therapeutic in a condition of abnormal neuronal hyperexcitability, that is, epilepsy. This review discusses recent efforts to isolate and transplant interneuron precursor cells derived from the...
Drug resistance remains one of the major challenges in epilepsy therapy. Identification of factors that contribute to therapeutic failure is crucial for future development of novel drugs and therapeutic strategies for difficult‐to treat epilepsies. For an expanded treatment of this topic see Jasper’s basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado‐Escueta...
Stem cell therapies are envisioned for severe neurologic disorders and intractable epilepsy. Methods to maintain and derive neural cells from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are providing insights into human nervous system development from stem cells and the future of stem cell therapy for epilepsy. For an expanded treatment of this topic see Jasper’s basic mechanisms of the epilepsies...
Deficiency of the brain’s endogenous anticonvulsant adenosine is a pathologic hallmark of epilepsy. Consequently, focal adenosine augmentation therapies (AATs) constitute a rational approach for seizure suppression. Focal adenosine augmentation and resulting seizure suppression can be realized by implanting adenosine‐releasing stem cells or polymers into epileptogenic brain regions. For an expanded...
Malformations of cortical development (MCDs) are common causes of seizures and developmental delay. Although considered to be irreversible, recent observations in animal models suggest that MCDs may remain responsive to corrective manipulations during prolonged time periods after malformations are formed. These findings may change our understanding of MCDs and open new therapeutic avenues. For an...
The α2δ proteins are auxiliary subunits of voltage‐gated calcium channels, but may also have other functions. Four mammalian α2δ genes have been cloned. There are several links between α2δ proteins and disease, including mice with mutated α2δ‐2, which exhibit spike‐wave epilepsy. Furthermore, the gabapentinoid drugs bind to α2δ‐1 and α2δ‐2. For an expanded treatment of this topic see Jasper’s basic mechanisms of the epilepsies....
Epilepsy research is undergoing a conceptual shift that is moving away from preventing seizures to preventing epilepsy by treatments that modify the epileptogenic process induced by a variety of brain insults. Evidence from animal experiments suggests that epilepsy prevention or modification is possible, but translating laboratory findings into successful therapies will require more scientific discoveries...
Neonatal seizures are a common problem inadequately treated with standard γ‐aminobutyric acid (GABA)ergic anticonvulsants. Understanding how the ontogeny of neuronal cation/chloride cotransporter expression renders GABAergic signaling excitatory in the neonatal brain has helped explain the increased seizure propensity and poor efficacy of GABAergic anticonvulsants in newborns, and is the rational...
Studies of deep brain stimulation in laboratory models of seizures and epilepsy are invaluable for understanding of mechanisms of stimulation and for identifying best targets and parameters of stimulation. Recent successes of clinical trials may give more impetus to laboratory studies, which in turn will further our clinical practice. For an expanded treatment of this topic see Jasper’s basic mechanisms of the epilepsies....
The dendritic arbor is the site of complex interactions between synaptic excitation and intrinsic excitability. This interaction is determined by the ion channels expressed on the dendritic arbor. The expression and gating properties of these channels can be perturbed in conditions associated with epilepsy that lead to hyperexcitability. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition...
FreeMarker template error (HTML_DEBUG mode; use RETHROW in production!)
Java method "org.springframework.web.servlet.support.RequestContext.getMessage(String)" threw an exception when invoked on org.springframework.web.servlet.support.RequestContext object "org.springframework.web.servlet.support.RequestContext@64cadd47"; see cause exception in the Java stack trace.
----
FTL stack trace ("~" means nesting-related):
- Failed at: ${springMacroRequestContext.getMessag... [in template "META-INF/freemarker-templates/spring.ftl" in macro "message" at line 28, column 22]
- Reached through: @spring.message "portal.searchResult... [in template "META-INF/freemarker-templates/portal/search/facets.ftl" at line 149, column 33]
----
Java stack trace (for programmers):
----
freemarker.core._TemplateModelException: [... Exception message was already printed; see it above ...]
at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:289)
at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:261)
at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:65)
at freemarker.core.MethodCall._eval(MethodCall.java:65)
at freemarker.core.Expression.eval(Expression.java:81)
at freemarker.core.DollarVariable.calculateInterpolatedStringOrMarkup(DollarVariable.java:96)
at freemarker.core.DollarVariable.accept(DollarVariable.java:59)
at freemarker.core.Environment.visit(Environment.java:363)
at freemarker.core.Environment.invoke(Environment.java:715)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:327)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.visit(Environment.java:369)
at freemarker.core.IteratorBlock$IterationContext.executedNestedContentForCollOrSeqListing(IteratorBlock.java:316)
at freemarker.core.IteratorBlock$IterationContext.executeNestedContent(IteratorBlock.java:272)
at freemarker.core.IteratorBlock$IterationContext.accept(IteratorBlock.java:243)
at freemarker.core.Environment.visitIteratorBlock(Environment.java:596)
at freemarker.core.IteratorBlock.acceptWithResult(IteratorBlock.java:108)
at freemarker.core.IteratorBlock.accept(IteratorBlock.java:94)
at freemarker.core.Environment.visit(Environment.java:327)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.process(Environment.java:306)
at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
at freemarker.core.Environment.visit(Environment.java:427)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:327)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.process(Environment.java:306)
at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
at freemarker.core.Environment.visit(Environment.java:427)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:327)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.process(Environment.java:306)
at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
at freemarker.core.Environment.visit(Environment.java:427)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:327)
at freemarker.core.Environment.visit(Environment.java:333)
at freemarker.core.Environment.process(Environment.java:306)
at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
at org.springframework.web.servlet.view.tiles3.TilesView.renderMergedOutputModel(TilesView.java:132)
at pl.edu.icm.synat.common.ui.tiles.FreeMarkerAndTilesView.renderMergedOutputModel(FreeMarkerAndTilesView.java:148)
at org.springframework.web.servlet.view.AbstractView.render(AbstractView.java:303)
at org.springframework.web.servlet.DispatcherServlet.render(DispatcherServlet.java:1243)
at org.springframework.web.servlet.DispatcherServlet.processDispatchResult(DispatcherServlet.java:1027)
at org.springframework.web.servlet.DispatcherServlet.doDispatch(DispatcherServlet.java:971)
at org.springframework.web.servlet.DispatcherServlet.doService(DispatcherServlet.java:893)
at org.springframework.web.servlet.FrameworkServlet.processRequest(FrameworkServlet.java:965)
at org.springframework.web.servlet.FrameworkServlet.doGet(FrameworkServlet.java:856)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:620)
at org.springframework.web.servlet.FrameworkServlet.service(FrameworkServlet.java:841)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:727)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:316)
at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.invoke(FilterSecurityInterceptor.java:126)
at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.doFilter(FilterSecurityInterceptor.java:90)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.access.ExceptionTranslationFilter.doFilter(ExceptionTranslationFilter.java:114)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.session.SessionManagementFilter.doFilter(SessionManagementFilter.java:122)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.authentication.AnonymousAuthenticationFilter.doFilter(AnonymousAuthenticationFilter.java:111)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.authentication.rememberme.RememberMeAuthenticationFilter.doFilter(RememberMeAuthenticationFilter.java:149)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.servletapi.SecurityContextHolderAwareRequestFilter.doFilter(SecurityContextHolderAwareRequestFilter.java:168)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.savedrequest.RequestCacheAwareFilter.doFilter(RequestCacheAwareFilter.java:48)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:207)
at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:184)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.jasig.cas.client.session.SingleSignOutFilter.doFilter(SingleSignOutFilter.java:100)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.header.HeaderWriterFilter.doFilterInternal(HeaderWriterFilter.java:64)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.context.request.async.WebAsyncManagerIntegrationFilter.doFilterInternal(WebAsyncManagerIntegrationFilter.java:53)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.session.ConcurrentSessionFilter.doFilter(ConcurrentSessionFilter.java:133)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.context.SecurityContextPersistenceFilter.doFilter(SecurityContextPersistenceFilter.java:91)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.access.channel.ChannelProcessingFilter.doFilter(ChannelProcessingFilter.java:152)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.saml.metadata.MetadataGeneratorFilter.doFilter(MetadataGeneratorFilter.java:87)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at pl.edu.icm.synat.portal.web.security.PortalLocaleFilter.doFilterInternal(PortalLocaleFilter.java:51)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:213)
at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:176)
at org.springframework.web.filter.DelegatingFilterProxy.invokeDelegate(DelegatingFilterProxy.java:344)
at org.springframework.web.filter.DelegatingFilterProxy.doFilter(DelegatingFilterProxy.java:261)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at ch.qos.logback.classic.helpers.MDCInsertingServletFilter.doFilter(MDCInsertingServletFilter.java:51)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at org.springframework.web.filter.CharacterEncodingFilter.doFilterInternal(CharacterEncodingFilter.java:85)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at pl.edu.icm.synat.portal.web.security.RemoteIpFilter.doFilter(RemoteIpFilter.java:75)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:219)
at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:196)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:220)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:122)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:504)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:170)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:103)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:421)
at org.apache.coyote.ajp.AjpProcessor.process(AjpProcessor.java:190)
at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:611)
at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:314)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1142)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:617)
at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
at java.lang.Thread.run(Thread.java:745)
Caused by: org.springframework.context.NoSuchMessageException: No message found under code 'portal.searchResult.facet.^journalVolume^journalNumber' for locale 'pl'.
at org.springframework.context.support.AbstractMessageSource.getMessage(AbstractMessageSource.java:159)
at org.springframework.context.support.DelegatingMessageSource.getMessage(DelegatingMessageSource.java:66)
at org.springframework.context.support.AbstractApplicationContext.getMessage(AbstractApplicationContext.java:1129)
at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:712)
at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:678)
at sun.reflect.GeneratedMethodAccessor295.invoke(Unknown Source)
at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.lang.reflect.Method.invoke(Method.java:497)
at freemarker.ext.beans.BeansWrapper.invokeMethod(BeansWrapper.java:1458)
at freemarker.ext.beans.ReflectionCallableMemberDescriptor.invokeMethod(ReflectionCallableMemberDescriptor.java:56)
at freemarker.ext.beans.MemberAndArguments.invokeMethod(MemberAndArguments.java:51)
at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:61)
... 179 more