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Objective
To evaluate acute and long‐term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self‐sustaining status epilepticus (SSSE).
Methods
Rats were treated with BRV (10 mg/kg) 10 min after initiation of perforant path stimulation (PPS) as early treatment; or BRV (10–300 mg/kg), DZP (1 mg/kg), or BRV (0.3–10 mg/kg) + DZP (1 mg/kg) 10...
Objective
To validate predictive models for neural antibody positivity and immunotherapy response in epilepsy.
Methods
We conducted a retrospective study of epilepsy cases at Mayo Clinic (Rochester‐MN; Scottsdale‐AZ, and Jacksonville‐FL) in whom autoimmune encephalopathy/epilepsy/dementia autoantibody testing profiles were requested (06/30/2014‐06/30/2016). An Antibody Prevalence in Epilepsy (APE)...
Objective
Seizures in mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis are thought to develop with various latency intervals after an initial transient brain insult. To study seizure dynamics after an initial transient precipitating insult in a systematic fashion, we utilized continuous video–electroencephalography (EEG) monitoring after the induction of status epilepticus...
Objective
To investigate whether mood disorders (MD) and anxiety disorders (AD) are associated with seizure control in patients with mesial temporal lobe epilepsy (MTLE). We compared patients without any current psychiatric disorder, patients with current MD and/or AD, patients with subsyndromic depression episodes (SSDE) and anxiety episodes (SSAE), and patients with family psychiatric history....
Objective
Currently, approximately 60–70% of patients with unilateral temporal lobe epilepsy (TLE) remain seizure‐free 3 years after surgery. The goal of this work was to develop a presurgical connectivity‐based biomarker to identify those patients who will have an unfavorable seizure outcome 1‐year postsurgery.
Methods
Resting‐state functional and diffusion‐weighted 3T magnetic resonance imaging...
Objective
Until now, it has been unclear if the three subsyndromes of adolescent‐onset generalized genetic epilepsy (GGE) differ in long‐term prognosis. Therefore, this study aimed to compare long‐term seizure outcome in juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic–clonic seizures alone (EGTCS).
Methods
This retrospective study is based...
Psychiatric and behavioral disorders are important aspects of epilepsy and have received increasing attention in the last several years. The literature upon which most of the field relies contains some biases that must be carefully examined and resolved in future studies. First, in the pediatric epilepsy literature, many reports find that children with epilepsy have high levels of behavioral and psychiatric...
Objective
Most epileptic seizures occur unexpectedly and independently of known risk factors. We aimed to evaluate the clinical significance of patients’ perception that weather is a risk factor for epileptic seizures.
Methods
Using a hospital‐based, bidirectional case‐crossover study, 604 adult patients admitted to a large university hospital in Central Germany for an unprovoked epileptic seizure...
Objectives
To evaluate dose–response relationship of BGG492 as add‐on therapy to 1–3 antiepileptic drugs in patients with partial‐onset seizures and to investigate safety and tolerability of BGG492.
Methods
This was a 12‐week, randomized, double‐blind, placebo‐controlled, phase II dose‐titration study (core study) with a 30‐week, flexible‐dose, open‐label extension. In the core study, patients...
Objective
To ascertain possible determinants of carbamazepine (CBZ)– and oxcarbazepine (OXC)–induced hyponatremia in a large cohort of people with epilepsy.
Methods
We collected data on serum sodium levels in people with epilepsy who were attending a tertiary epilepsy center while on treatment with CBZ or OXC. We defined hyponatremia as Na+ ≤134 mEq/L and severe hyponatremia as Na+ ≤128 mEq/L....
Objective
To describe the developmental trajectories of quality of life (QoL) in a large cohort of children with epilepsy, and to assess the relative contribution of clinical, psychosocial, and sociodemographic variables on QoL trajectories.
Methods
Five assessments during a 28‐month prospective cohort study were used to model trajectories of QoL. Participants were recruited with their parents...
Objective
It is well known that sleep‐related motor seizures can originate from the temporal lobe. However, little is known about the clinical features of minor motor manifestations during sleep in patients with temporal lobe epilepsy. The main objective of our study was to verify the existence of minor motor events during sleep in patients with mesial temporal lobe epilepsy (MTLE) and to define...
Objective
Temporal lobe epilepsy (TLE) is commonly associated with depression, anxiety, and cognitive impairment. Despite significant progress in our understanding of the pathophysiology of TLE, it remains the most common form of refractory epilepsy. Enriched environment (EE) has a beneficial effect in many neuropsychiatric disorders. However, the effect of EE on cognitive changes in chronic TLE...
Objective
To evaluate factors predicting efficacy, retention, and tolerability of add‐on brivaracetam (BRV) in clinical practice.
Methods
A multicenter, retrospective cohort study recruiting all patients who started BRV between February and November 2016 with observation time between 3 and 12 months.
Results
Of a total of 262 patients (mean age 40, range 5–81 years, 129 male) treated with BRV,...
Objective
Given that only the free non–protein‐bound concentration of an antiepileptic drug (AED) crosses the blood–brain barrier, entering the brain and producing an antiepileptic effect, knowledge and measurement of the free drug fraction is important. Such data are sparse, particularly for newer AEDs, and have arisen from the use of disparate methodologies and settings over the past six decades...
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