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PurposeTo determine whether AMPA receptor (AMPAR) antagonist NBQX can prevent early mammalian target of rapamycin (mTOR) pathway activation and long‐term sequelae following neonatal seizures in rats, including later‐life spontaneous recurrent seizures, CA3 mossy fiber sprouting, and autistic‐like social deficits.
MethodsLong‐Evans rats experienced hypoxia‐induced neonatal seizures (HS) at postnatal...
Objective
Perampanel (PER), a selective non‐competitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)‐receptor antagonist, exhibits broad‐spectrum anticonvulsant activity in several seizure models, but its potential disease‐modifying effects have not been investigated. Because of the relevance of AMPA receptors in epileptogenesis and psychiatric comorbidities, we studied the effects...
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