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In this response to a commentary by Ben‐Ari and Delpire on our recent study on the pharmacology of neonatal seizures in a novel, physiologically validated rat model of birth asphyxia, we wish to rectify their inaccurate descriptions of our model and data. Furthermore, because Ben‐Ari and Delpire suggest that negative data on bumetanide from preclinical and clinical trials of neonatal seizures have...
Objective
The study was aimed to define appropriate levetiracetam dosing regimens from available published pharmacokinetics (PK) studies in critically ill patients with and without cirrhosis receiving continuous renal replacement therapy (CRRT) via Monte Carlo simulation (MCS).
Methods
Mathematical pharmacokinetic models were developed using published demographic and PK data in adult critically...
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