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Background and purposeUric acid (UA) has been studied extensively as a valuable biomarker of Parkinson's disease (PD), but its relationship with non‐motor symptoms (NMS) in de novo PD has been poorly investigated. Our aim was to evaluate the usefulness of baseline serum UA as a marker of NMS progression in newly diagnosed PD.
MethodsSixty‐nine newly diagnosed PD patients were enrolled. At baseline,...
Background and purpose
Oxidative stress is a central pathogenic mechanism of Parkinson's disease (PD), and the heme oxygenase (HO) bilirubin pathway is one of the main mammalian antioxidative defences. Indeed, there is growing evidence of HO−bilirubin upregulation from early phases of PD. Our aim was to investigate bilirubin as a possible biomarker of PD diagnosis and progression.
Methods
A cross‐sectional...
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