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The γ‐glutamyl hydrolase (GGH) gene plays an important role in methotrexate (MTX) metabolism, ensuring that MTX polyglutamates (MTX‐(Glu)n) could be converted back into MTX. Accumulation of MTX‐(Glu)n is a problem in MTX therapy. SNP 452 C>T has been reported to associate with lower catalytic activity and higher accumulation of long‐chain MTX‐(Glu)n in patients treated with higher doses of MTX...
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