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Integration and joint analysis of omics profiles derived on the genome, transcriptome, proteome and metabolome levels is a natural next step in realizing a Systems Biology view of cellular processes. However, merging, e.g. mRNA concentration and protein abundance profiles, is not straightforward, as a direct overlap of differentially regulated/abundant features, resulting from transcriptomics and...
Azathioprine, an immunosuppressant, has gained a prominent position in the clinic for prevention of graft rejection in organ transplants, as well as dermatological autoimmune diseases. However, according to a number of research reports, hepatotoxicity, as one of the side effects, is a major obstacle in azathioprine therapy. In this study, an integrated toxicoproteomic and toxicotranscriptomic analysis...
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