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The inhibition of aggregation and disaggregation effect of a β‐sheet breaker was evaluated by in situ electrochemistry of the Aβ1–42 peptide. The exposition of 10tyr residue was followed using a carbon nanotubes modified glassy carbon electrode immersed directly in the solution. Both processes were studied at a ratio of Aβ/β‐sheet breaker of 10 µM : 100 µM which is effective in vitro. This approach...
AD (Alzheimer’s disease) is a progressive neurodegenerative disorder characterized by the cerebral accumulation of fibrillar amyloid‐beta (Aβ) aggregates. Here we present the electrochemistry of two novel sym‐triazine derivatives (TAE‐1, TAE‐2) as modulators of Aβ1–42 aggregation in vitro. Incubation studies conducted at physiological conditions demonstrated strong inhibition of β‐sheet fibril formation...
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